The Lymphocyte Map™
The Lymphocyte MAP™
Comprehensive Lymphocyte Immunophenotyping
“Cyrex Immunophenotyping can change the way we evaluate our patients and help them achieve their immune harmony”
Aristo Vojdani, PhD
The Lymphocyte MAP™, is an innovative test which establishes a new standard in screening the immune system. It measures the integrity of the immune system at the cellular level to help identify a patient’s immune status and immunotype(s), based on 35 key determinations.
It utilizes an advanced proprietary flow cytometry method, which combines cutting-edge laser technology with monoclonal antibodies, to precisely measure the properties of living cells such as size, shape, density and granularity which results in a precise count of various lymphocyte subpopulations.
This helps identify patterns of imbalance of T cells, B cells and Natural Killer cells. It then organizes these patterns into specific immunotypes to provide an invaluable picture of the immune system.
Cbc vs Basic Immunophenotyping vs the Lymphocyte Map
This breakthrough panel establishes a new industry standard in screening the immune system.
Complete Blood Cell Count (CBC)
Part of a regular check up
Basic Lymphocyte Immunophenotyping
Performed by some labs for the purpose of detecting certain immune deficiencies including AIDS
The Lymphocyte MAP™
Exclusive immunophenotyping to help identify immune deficiency, immune over-activity, infections, inflammation, autoimmunities, allergies, asthma, hypersensitivities, and cancers
The Lymphocyte Map™ – Numbers, Ratios, Percentages and Activity – Nrpa
Lymphocytes and their subpopulations are the key elements of the immune system. In adults, they account for about 20-49% of the total number of white blood cells. It would be vitally important to measure decrease or increase in the percentage and number of these important lymphocytes. It is the numbers, ratios, percentages and activity level of these lymphocytes, and their subpopulations which are responsible for protection against various environmental factors, including viruses.
When healthy, these NRPAs are in a precise and pre-determined relationship to one-another. It is the disruption of these finely balanced relationships which can compromise the immune function.
These are NOT measured by a CBC test, which is just part of a yearly checkup. There is a significant difference between lymphocyte immunophenotyping and the complete blood count (CBC), which is used for checking the overall health of a patient.
A CBC could be absolutely normal, but the patient could actually be suffering from immune dysfunction, which includes immune deficiencies, hidden inflammation, autoimmunities, hypersensitivities and allergies induced by environmental triggers. These immune disorders can be detected by the advanced immunophenotyping of lymphocytes done by Cyrex Labs.
Key Features of the Lymphocyte Map
Fourteen immunotypes uniquely designed to capture and highlight important immune trends revealed due to the comprehensive number of determinations tested.
T-helper-1 or T-helper -2 Dominance (Immunotypes 6 and 7) Includes the Cyrex Fluorescence Activated Cell Test (Cyrex FACT™), a breakthrough proprietary process developed by expert Cyrex immunologists, to classify Th1/Th2 balance or imbalance, based on the specific clusters of differentiation (CD markers) on the surface membranes on Th1 or Th2 cells, and not on the measurement of Th1/Th2-associated cytokine levels in the blood, commonly used by other laboratories.
Regulatory T cells or Tregs (Immunotype 8) maintain the balance between Th1 and Th2. A low number of Tregs may result in the breakdown in peripheral, central and oral tolerance, immune suppression, immune deficiencies, some autoimmune disorders, increased infections and cancer.
T-helper-17 dominance. (Immunotype 9) Includes the Cyrex FACT™ process based on direct measurement of cells based on the CD markers on their surface membranes of the cells, not by measuring IL-17 levels in the blood.
Patterns of disturbance in NK, cytotoxic NK and NK T cells. (Immunotypes 12 and 13) these immmunotypes are characterized by imbalanced natural killer (NK) cells, cytotoxic NK cells and NK T cells. They are the body’s soldiers whose job is to destroy different pathogens and varieties of cancer cells.
Immunotype with low or high CD57+ and its combination with CD16+ NK cells and CD8+ T cells. (Immunotype 14) CD57+ NK cells are highly differentiated long-lived cells that are more efficient in the killing of pathogen-infected cells and cancers, particularly during aging. Due to their efficiency at the killing of their targets, elevations in the number of CD57+ NK cells are associated with better outcomes for patients with cancers and some autoimmune diseases, while low levels are associated with lower overall survival from cancer.
Clinical Uses
The Lymphocyte MAP can:
Provide you with very useful surrogate markers for the diagnosis of autoimmune diseases, immune deficiencies, allergies and hypersensitivities.
Give you an invaluable picture of underlying immune imbalances that may trigger complex diseases.
Help you see how environmental triggers could affect your immune system, possibly resulting in a disease.
Help you identify immune conditions at an earlier stage, which if not addressed, may cause over-reaction (autoimmunity), or under-reaction (immune deficiencies) of the immune system, thus gauge existing susceptibilities.
Give you a more precise immune picture to help plan a treatment regimen or monitor its success.
The Lymphocyte MAP opens a new world for the immune system analysis and identifies important correlations with disease conditions.
Lymphocyte Map™ Determinations:
Total WBC
Total Lymphocyte
% Lymphocyte
Total T Cell
% T Cell
Total B Cell
% B Cell
T Cell/B Cell Ratio
Total T-Helper (CD4) Cell
% T-Helper (CD4) Cell
Total Cytotoxic (CD8) T Cell
% Cytotoxic (CD8) T Cell
CD4/CD8 Ratio
Total T-Helper-1 Cell
% T-Helper-1 Cell
Total T-Helper-2 Cell
% T-Helper-2 Cell
TH1/TH2 Ratio
Total T-Helper-17 (Th17)
% T-Helper-17
Total Regulatory T Cell (Treg)
% Regulatory T Cell
Th17/Treg Ratio
Total NK Cell (CD56+)
% NK Cell (CD56+)
Total Cytotoxic NK cells (CD16+)
% Cytotoxic NK cells (CD16+)
Total NKT (CD56+ CD16+ T Cell)
% NKT (CD56+ CD16+ T Cell)
Total CD3- CD57+ Lymphocyte
% CD3- CD57+ Lymphocyte
Total CD57+ CD8+ T Cell
% CD57+ CD8+ T Cell
Total CD57+ CD16 NK Cell
% CD57+ CD16 NK Cell
To Book This Test, and to See if This Test is Right for You, Please First Book a Naturopathic Consult With the Naturopathic Doctor
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